Why do some intervertebral discs degenerate, when others (in the same spine) do not?

This article discusses the process of disc degeneration and the reasons discs degenerate.  The good news is that they conclude that moderate mechanical loading, strengthens all spinal tissues. ~ Dr. Broussard

Clin Anat. 2015 Mar;28(2):195-204. doi: 10.1002/ca.22404. Epub 2014 Apr 19.
Adams MA

Abstract
This review suggests why some discs degenerate rather than age normally. Intervertebral discs are avascular pads of fibrocartilage that allow movement between vertebral bodies. Human discs have a low cell density and a limited ability to adapt to mechanical demands. With increasing age, the matrix becomes yellowed, fibrous, and brittle, but if disc structure remains intact, there is little impairment in function, and minimal ingrowth of blood vessels or nerves. Approximately half of old lumbar discs degenerate in the sense of becoming physically disrupted. The posterior annulus and lower lumbar discs are most affected, presumably because they are most heavily loaded. Age and genetic inheritance can weaken discs to such an extent that they are physically disrupted during everyday activities. Damage to the endplate or annulus typically decompresses the nucleus, concentrates stress within the annulus, and allows ingrowth of nerves and blood vessels. Matrix disruption progresses by mechanical and biological means. The site of initial damage leads to two disc degeneration “phenotypes”: endplate-driven degeneration is common in the upper lumbar and thoracic spine, and annulus-driven degeneration is common at L4-S1. Discogenic back pain can be initiated by tissue disruption, and amplified by inflammation and infection. Healing is possible in the outer annulus only, where cell density is highest. We conclude that some discs degenerate because they are disrupted by excessive mechanical loading. This can occur without trauma if tissues are weakened by age and genetic inheritance. Moderate mechanical loading, in contrast, strengthens all spinal tissues, including discs.

KEYWORDS:
ageing; degeneration; injury; intervertebral disc; review

PMID: 24753325 DOI: 10.1002/ca.22404

PubMed Reference