Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.
- Family history of cardiovascular disease
- Personal history of myocardial infarction, peripheral artery disease, or coronary artery disease
- Obesity
- Diabetes
- Hypertension
- Thyroid disorders
- Stress
- Chronic illness (including chronic fatigue)
- Diets high in bad saturated and trans fats
- Sedentary lifestyle
- Use of alcohol,nicotine,drugs (including certain medications)
- Use of oral contraceptives
- Hormonal imbalances (estradiol, cortisol, insulin, melatonin)
- Post-menopause
- Renal disease
- Earlobe crease
- Total Cholesterol
- LDL
- HDL
- Homocysteine
- Triglycerides
- Lipoprotein(a)
- Apolipoprotein A-1
- Apolipoprotein B
- Ratio of Apo B/Apo A-1
- Fibrinogen
- C-Reactive Protein
- Motamed M, Pelekoudas N. The predictive value of diagonal ear-lobe crease sign.Int J Clin Pract. 1998 Jul-Aug;52(5):305-6.
- Miric D, Fabijanic D, Giunio L, Eterovic D, Culic V, Bozic I, Hozo I. Dermatological indicators of coronary risk: a case-control study. Int J Cardiol. 1998 Dec 31;67(3):251-5.
- Cheng TO. More research needed on the association between diagonal earlobe crease and coronary artery disease. Arch Intern Med. 2000 Aug 14-28;160(15):2396-7.
- Eber B, Delgado P. More on the diagonal earlobe crease as a marker of coronary artery disease. Am J Cardiol. 1993 Oct 1;72(11):861.
- Tranchesi Junior B, Barbosa V, de Albuquerque CP, Caramelli B, Gebara O, dos Santos Filho RD, Nakano O, Bellotti G, Pileggi F. Diagonal earlobe crease as a marker of the presence and extent of coronary atherosclerosis. Am J Cardiol. 1992 Dec 1;70(18):1417-20.
- Cheng TO. Ear lobe crease and coronary artery disease. J Am Geriatr Soc. 1991 Mar;39(3):315-6.
- Kenny DJ, Gilligan D. Ear lobe crease and coronary artery disease in patients undergoing coronary arteriography. Cardiology. 1989;76(4):293-8.
- Cumberland GD, Riddick L, Vinson R. Earlobe creases and coronary atherosclerosis. The view from forensic pathology. Am J Forensic Med Pathol. 1987 Mar;8(1):9-11.
- Gibson TC, Ashikaga T. The ear lobe crease sign and coronary artery disease in aortic stenosis. Clin Cardiol. 1986 Aug;9(8):388-90.
- Gutiu I, el Rifai C, Mallozi M. Relation between diagonal ear lobe crease and ischemic chronic heart disease and the factors of coronary risk. Med Interne. 1986 Apr-Jun;24(2):111-6.
- Elliott WJ. Ear lobe crease and coronary artery disease. 1,000 patients and review of the literature. Am J Med. 1983 Dec;75(6):1024-32.
- Shoenfeld Y, Mor R, Weinberger A, Avidor I, Pinkhas J. Diagonal ear lobe crease and coronary risk factors. J Am Geriatr Soc. 1980 Apr;28(4):184-7. 13:Kristensen BO. Ear-lobe crease and vascular complications in essential hypertension.Lancet. 1980 Feb 2;1(8162):265.
- Kaukola S, Manninen V, Valle M, Halonen PI. Ear-lobe crease and coronary atherosclerosis. Lancet. 1979 Dec 22-29;2(8156-8157):1377.
- Haines SJ. Nonspecificity of ear-crease sign in coronary-artery disease. N Engl J Med. 1977 Nov 24;297(21):1181.
- Frank ST. Ear-crease sign of coronary disease. N Engl J Med. 1977 Aug 4;297(5):282.
- Rhoads GG, Yano K. Ear-lobe crease and coronary-artery heart disease. Ann Intern Med. 1977 Aug;87(2):245
- Lichstein E, Chadda KD, Naik D, Gupta PK. Diagonal ear-lobe crease: prevalence and implications as a coronary risk factor. N Engl J Med. 1974 Mar 14;290(11):615-6
The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Grisanti and his functional medicine community. Dr. Grisanti encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Visit www.FunctionalMedicineUniversity.com for more information on our training in functional medicine. Look for practitioners who have successfully completed the Functional Medicine University’s Certification Program (CFMP) www.functionalmedicinedoctors.com. This content may be copied in full, with copyright, contact, creation and information intact, without specific permission, when used only in a not-for-profit format. If any other use is desired, permission in writing from Dr. Grisanti is required.